Multicenter validation of a mouse model for cow's milk allergy to assess the allergenicity of hydrolysed cow's milk based infant formulae
نویسندگان
چکیده
Background The EC-directive 2006/141/E requires objective and scientifically verified data to claim hypoallergenicity of hydrolysed formulae. However, no validated animal models are currently available to assess the residual sensitising capacity, although guinea pig assays are frequently used. This study is part of a multi-phase project which aims to validate a recently developed mouse model to assess the potential allergenicity of hydrolysed cow’s milk based infant formulae. The discriminatory power of a mouse allergy model for cow’s milk allergy to distinguish sensitizing properties of cow’s milk products was evaluated in 4 independent research centers.
منابع مشابه
The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow’s milk protein allergy
Infants diagnosed with allergy to cow's milk protein (CMP) are fed extensively hydrolysed cow's milk formulas, modified soy formulas or even amino acid-based formulas. Hydrolysed rice protein infant formulas have become available and have been shown to be well tolerated by these infants. A prospective open, randomized clinical study to compare the clinical tolerance of a new hydrolysed rice pro...
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